HMM Summary Page: TIGR04429

FunctionPhr family secreted Rap phosphatase inhibitor
Trusted Cutoff25.00
Domain Trusted Cutoff25.00
Noise Cutoff23.70
Domain Noise Cutoff23.70
Isology Typesubfamily_domain
HMM Length28
AuthorHaft DH
Entry DateApr 4 2013 3:17PM
Last ModifiedApr 4 2013 3:17PM
CommentPhr peptides are short peptides, best conserved in their amino-terminal regions, that are almost always encoded immediately downstream of a Rap phosphatase. A portion of the Phr peptide is secreted, enters another cell, and forms a quorum-sensing system by inhibiting its Rap phosphatase partner. The set of Phr peptides recognized by this N-terminal region model is disjoint from the PhrC/PhrF set recognized by Pfam model PF11131.
ReferencesRN [1] RM PMID:9689219 RT Characterization of a family of bacterial response regulator aspartyl-phosphate (RAP) phosphatases. RA Reizer J, Reizer A, Perego M, Saier MH Jr RL Microb Comp Genomics. 1997;2(2):103-11.