HMM Summary Page: TIGR04428

Functiontryptophan 2-C-methyltransferase
Gene SymboltsrT
Trusted Cutoff500.00
Domain Trusted Cutoff500.00
Noise Cutoff300.00
Domain Noise Cutoff300.00
Isology Typeequivalog
EC Number2.1.1.106
HMM Length558
AuthorHaft DH
Entry DateApr 4 2013 12:31PM
Last ModifiedApr 4 2013 12:31PM
CommentMembers of this family are the B12-binding domain/radical SAM domain enzyme tryptophan methyltransferase, named TsrT in the cassette for thiostrepton biosynthesis. Thiostrepton and related thiopeptides are synthesized by extensive modification of a ribosomally translated product, but this enzyme is involved in a pathway that converts a free Trp residue to a quinaldic acid moiety before it is appended.
ReferencesRN [1] RM PMID:23064318 RT Thiostrepton tryptophan methyltransferase expands the chemistry of radical SAM enzymes. RA Pierre S, Guillot A, Benjdia A, Sandstrom C, Langella P, Berteau O RL Nat Chem Biol. 2012 Dec;8(12):957-9.