Accession | TIGR04428 |
Name | B12_rSAM_trp_MT |
Function | tryptophan 2-C-methyltransferase |
Gene Symbol | tsrT |
Trusted Cutoff | 500.00 |
Domain Trusted Cutoff | 500.00 |
Noise Cutoff | 300.00 |
Domain Noise Cutoff | 300.00 |
Isology Type | equivalog |
EC Number | 2.1.1.106 |
HMM Length | 558 |
Author | Haft DH |
Entry Date | Apr 4 2013 12:31PM |
Last Modified | Apr 4 2013 12:31PM |
Comment | Members of this family are the B12-binding domain/radical SAM domain enzyme tryptophan methyltransferase, named TsrT in the cassette for thiostrepton biosynthesis. Thiostrepton and related thiopeptides are synthesized by extensive modification of a ribosomally translated product, but this enzyme is involved in a pathway that converts a free Trp residue to a quinaldic acid moiety before it is appended. |
References | RN [1]
RM PMID:23064318
RT Thiostrepton tryptophan methyltransferase expands the chemistry of radical SAM enzymes.
RA Pierre S, Guillot A, Benjdia A, Sandstrom C, Langella P, Berteau O
RL Nat Chem Biol. 2012 Dec;8(12):957-9. |