HMM Summary Page: TIGR04427

FunctiondTDP-4-dehydro-6-deoxyglucose aminotransferase
Trusted Cutoff650.00
Domain Trusted Cutoff650.00
Noise Cutoff580.00
Domain Noise Cutoff580.00
Isology Typeequivalog
EC Number2.-.-.-
HMM Length390
AuthorHaft DH
Entry DateMar 29 2013 2:50PM
Last ModifiedMar 29 2013 2:50PM
CommentMembers of this family are pyridoxal phosphate-dependent aminotransferases that convert TDP-4-keto-6-deoxy-D-glucose to the 4-amino sugar form, TDP-4-amino-4,6-dideoxy-D-glucose. In Streptomyces venezuelae, this enzyme is designated DesI, catalyzing the third of six steps in the biosynthesis of TDP-D-desosamine, a component of a number of different macrolide antibiotics made by that organism. Related proteins, scoring below the trusted cutoff, include sugar aminotranferases in O-antigen biosynthesis regions.
ReferencesRN [1] RM PMID:17630700 RT Molecular architecture of DesI: a key enzyme in the biosynthesis of desosamine. RA Burgie ES, Holden HM RL Biochemistry. 2007 Aug 7;46(31):8999-9006.