HMM Summary Page: TIGR04426

FunctionTDP-4-amino-4,6-dideoxy-D-glucose deaminase
Gene SymboldesII
Trusted Cutoff450.00
Domain Trusted Cutoff450.00
Noise Cutoff80.00
Domain Noise Cutoff80.00
Isology Typeequivalog
HMM Length468
AuthorHaft DH
Entry DateMar 29 2013 2:20PM
Last ModifiedMar 29 2013 2:20PM
CommentMembers of this protein family, including DesII, are radical SAM enzymes that deaminate TDP-4-amino-4,6-dideoxy-D-glucose to TDP-3-keto-4,6-dideoxy-D-glucose. This is the fourth step of the six step pathway in Streptomyces venezuelae for synthesizing D-desosamine, or 3-(dimethylamino)-3,4,6-trideoxyglucose, a precursor for many macrolide antibiotics.
ReferencesRN [1] RM PMID:19746907 RT Characterization and mechanistic studies of DesII: a radical S-adenosyl-L-methionine enzyme involved in the biosynthesis of TDP-D-desosamine. RA Szu PH, Ruszczycky MW, Choi SH, Yan F, Liu HW RL J Am Chem Soc. 2009 Oct 7;131(39):14030-42.