HMM Summary Page: TIGR04426
| Accession | TIGR04426 |
| Name | rSAM_desII |
| Function | TDP-4-amino-4,6-dideoxy-D-glucose deaminase |
| Gene Symbol | desII |
| Trusted Cutoff | 450.00 |
| Domain Trusted Cutoff | 450.00 |
| Noise Cutoff | 80.00 |
| Domain Noise Cutoff | 80.00 |
| Isology Type | equivalog |
| HMM Length | 468 |
| Author | Haft DH |
| Entry Date | Mar 29 2013 2:20PM |
| Last Modified | Mar 29 2013 2:20PM |
| Comment | Members of this protein family, including DesII, are radical SAM enzymes that deaminate TDP-4-amino-4,6-dideoxy-D-glucose to TDP-3-keto-4,6-dideoxy-D-glucose. This is the fourth step of the six step pathway in Streptomyces venezuelae for synthesizing D-desosamine, or 3-(dimethylamino)-3,4,6-trideoxyglucose, a precursor for many macrolide antibiotics. |
| References | RN [1] RM PMID:19746907 RT Characterization and mechanistic studies of DesII: a radical S-adenosyl-L-methionine enzyme involved in the biosynthesis of TDP-D-desosamine. RA Szu PH, Ruszczycky MW, Choi SH, Yan F, Liu HW RL J Am Chem Soc. 2009 Oct 7;131(39):14030-42. |