HMM Summary Page: TIGR04419

FunctionHemN-related non-iron pseudo-SAM protein PsgB
Gene SymbolpsgB
Trusted Cutoff300.00
Domain Trusted Cutoff300.00
Noise Cutoff200.00
Domain Noise Cutoff200.00
Isology Typeequivalog
HMM Length378
AuthorHaft DH
Entry DateMar 1 2013 12:55PM
Last ModifiedMar 1 2013 12:55PM
CommentMembers of this protein family are related to radical SAM enzymes HemN (oxygen-independent coproporphyrinogen III oxidase) and HutW (a putative heme utilization enzyme) but lack the signature CxxxCxxC motif for 4Fe-4S binding. Members occur exclusively in Borrelia, which appears to live without iron, as the only radical SAM enzyme homolog in any Borrelia genome. We designate this enzyme PsgB (Pseudo-SAM, Genus Borrelia).
ReferencesRN [1] RM PMID:10834845 RT Lack of a role for iron in the Lyme disease pathogen. RA Posey JE, Gherardini FC RL Science. 2000 Jun 2;288(5471):1651-3.