HMM Summary Page: TIGR04394

Functioncholine trimethylamine-lyase
Gene SymbolcutC
Trusted Cutoff1050.00
Domain Trusted Cutoff1050.00
Noise Cutoff825.00
Domain Noise Cutoff825.00
Isology Typeequivalog
EC Number4.3.99.4
HMM Length789
AuthorHaft DH
Entry DateDec 21 2012 12:26PM
Last ModifiedDec 21 2012 12:26PM
CommentMembers of this family, homologs to pyruvate formate-lyases and benzylsuccinate synthases, are glycine radical enzymes that appear to act as choline TMA-lyase, that is, to perform a C-N bond cleavage turning choline into trimethylamine (TMA) plus acetaldehyde. The gene symbol is cutC, for choline utilization. The activase, CutD, is a radical SAM enzyme.
ReferencesRN [1] RM PMID:23151509 RT Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme. RA Craciun S, Balskus EP RL Proc Natl Acad Sci U S A. 2012 Nov 14.
Genome PropertyGenProp1076: choline TMA-lyase system (HMM)