HMM Summary Page: TIGR04394
| Accession | TIGR04394 |
| Name | choline_CutC |
| Function | choline trimethylamine-lyase |
| Gene Symbol | cutC |
| Trusted Cutoff | 1050.00 |
| Domain Trusted Cutoff | 1050.00 |
| Noise Cutoff | 825.00 |
| Domain Noise Cutoff | 825.00 |
| Isology Type | equivalog |
| EC Number | 4.3.99.4 |
| HMM Length | 789 |
| Author | Haft DH |
| Entry Date | Dec 21 2012 12:26PM |
| Last Modified | Dec 21 2012 12:26PM |
| Comment | Members of this family, homologs to pyruvate formate-lyases and benzylsuccinate synthases, are glycine radical enzymes that appear to act as choline TMA-lyase, that is, to perform a C-N bond cleavage turning choline into trimethylamine (TMA) plus acetaldehyde. The gene symbol is cutC, for choline utilization. The activase, CutD, is a radical SAM enzyme. |
| References | RN [1] RM PMID:23151509 RT Microbial conversion of choline to trimethylamine requires a glycyl radical enzyme. RA Craciun S, Balskus EP RL Proc Natl Acad Sci U S A. 2012 Nov 14. |
| Genome Property | GenProp1076: choline TMA-lyase system (HMM) |