HMM Summary Page: TIGR04391

FunctionCcmD family protein
Trusted Cutoff24.00
Domain Trusted Cutoff24.00
Noise Cutoff22.00
Domain Noise Cutoff22.00
Isology Typesubfamily
HMM Length36
AuthorHaft DH
Entry DateNov 30 2012 10:25AM
Last ModifiedNov 30 2012 10:25AM
CommentMembers of this protein family are small (typically less than 50 amino acids in length), with the first half highly hydrophobic like transmembrane alpha helices and containing a nearly invariant tyrosine residue. Members from the Desulfovibrionales appear in the position of ccmD of system I c-type cytochrome biogenesis operons (see PF04995). This family and PF04995 appear very similar in sequence properties, but the very low level of actual sequence identify makes it unclear that the similarity reflects homology per se.
ReferencesRN [1] RM PMID:18326572 RT Topology and function of CcmD in cytochrome c maturation. RA Richard-Fogal CL, Frawley ER, Kranz RG RL J Bacteriol. 2008 May;190(10):3489-93.
Genome PropertyGenProp0678: c-type cytochrome biogenesis, system I (HMM-CLUST)