HMM Summary Page: TIGR04368

Functionglutamate 2,3-aminomutase
Gene Symboleam
Trusted Cutoff650.00
Domain Trusted Cutoff650.00
Noise Cutoff525.00
Domain Noise Cutoff525.00
Isology Typeequivalog
EC Number5.4.3.9
HMM Length404
AuthorHaft DH
Entry DateAug 17 2012 9:49AM
Last ModifiedAug 17 2012 9:49AM
CommentMembers of this family are glutamate 2,3-aminomutase, a radical SAM enzyme with a pyridoxal phosphate group. It is closely related to lysine 2,3-aminomutase, but distinguished by architecture (longer N-terminal region, shorter C-terminal region) and replacement of key lysine-binding residues Asp293 and Asp330 (inferred from the crystal structure) by glutamate-binding residues Lys and Asn. Activity was demonstrated for sequences from Clostridium difficile, Thermoanaerobacter tengcongensis MB4, and Syntrophomonas wolfei str. Goettingen. The action of this enzyme creates beta-glutamate, an osmolyte.
ReferencesRN [1] RM PMID:17222594 RT Glutamate 2,3-aminomutase: a new member of the radical SAM superfamily of enzymes. RA Ruzicka FJ, Frey PA RL Biochim Biophys Acta. 2007 Feb;1774(2):286-96.
Genome PropertyGenProp1070: beta-glutamate biosynthesis (HMM)