HMM Summary Page: TIGR04366

Functioncupin fold metalloprotein, WbuC family
Trusted Cutoff42.00
Domain Trusted Cutoff42.00
Noise Cutoff39.00
Domain Noise Cutoff39.00
Isology Typesubfamily
HMM Length132
AuthorHaft DH
Entry DateAug 7 2012 9:55AM
Last ModifiedAug 12 2012 6:56PM
CommentMembers of this family show sequence similarity to cupin fold proteins (see PF07883), including conserved His residues likely to serve as metal-binding ligands. Many members occur in bacterial O-antigen biosynthesis regions. Some members have acquired the gene symbol wbuC (e.g. Jarvis, et al, 2011), but publications using this term do not ascribe a function.
ReferencesRN [1] RM PMID:21531829 RT Molecular characterization of Cronobacter lipopolysaccharide O-antigen gene clusters and development of serotype-specific PCR assays. RA Jarvis KG, Grim CJ, Franco AA, Gopinath G, Sathyamoorthy V, Hu L, Sadowski JA, Lee CS, Tall BD RL Appl Environ Microbiol. 2011 Jun;77(12):4017-26. RN [2] RM PMID:18948958 RT Protein-folding location can regulate manganese-binding versus copper- or zinc-binding. RA Tottey S, Waldron KJ, Firbank SJ, Reale B, Bessant C, Sato K, Cheek TR, Gray J, Banfield MJ, Dennison C, Robinson NJ RL Nature. 2008 Oct 23;455(7216):1138-42.