HMM Summary Page: TIGR04354

Functionamphi-Trp domain
Trusted Cutoff31.00
Domain Trusted Cutoff31.00
Noise Cutoff28.00
Domain Noise Cutoff28.00
Isology Typedomain
HMM Length67
AuthorHaft DH
Entry DateJul 12 2012 9:57AM
Last ModifiedAug 12 2012 6:56PM
CommentThis domain usually comprises most of the span of bacterial or archaeal proteins with a length of about 90 amino acids. Some members, however, are extended by one or two copies of domain PF07411 in the C-terminal region. No residue in this domain is invariant. A striking feature of this domain is a C-terminal region that alternates strongly charged with strongly hydrophobic residues and usually ends with a Trp residue, e.g. LEIEIEW or FEIKVRW, suggesting an amphipathic beta strand structure. We suggest the name amphi-Trp for this domain. Some members of this function occur regularly in genomic contexts that include putative kinases of unknown specificity related to (but distinct from) HPr kinase, a Ser-specific protein kinase. The function is unknown.
Genome PropertyGenProp1066: uncharacterized cassette GAK (Grasp, Amphipathic, Kinase) (HMM-CLUST)