| Accession | TIGR04336 |
| Name | AmmeMemoSam_B |
| Function | AmmeMemoRadiSam system protein B |
| Gene Symbol | amrB |
| Trusted Cutoff | 26.00 |
| Domain Trusted Cutoff | 26.00 |
| Noise Cutoff | 20.00 |
| Domain Noise Cutoff | 20.00 |
| Isology Type | hypoth_equivalog |
| HMM Length | 270 |
| Author | Haft DH |
| Entry Date | Jun 5 2012 12:22PM |
| Last Modified | Aug 12 2012 6:56PM |
| Comment | Members of this protein family belong to the same domain family as the mammalian protein Memo (Mediator of ErbB2-driven cell MOtility). Members of the present family occur as part of a three gene system with an uncharacterized radical SAM enzyme and a homolog of the mammalian protein AMMECR1, a mammalian protein named for AMME - Alport syndrome, Mental Retardation, Midface hypoplasia, and Elliptocytosis. Memo in humans has protein-protein interaction activity with binding of phosphorylated Try, but members of this family may be active as enzymes, as suggested by homology to a class of nonheme iron dioxygenases. |
| References | RN [1]
RM PMID:18045866
RT Memo is homologous to nonheme iron dioxygenases and binds an ErbB2-derived phosphopeptide in its vestigial active site.
RA Qiu C, Lienhard S, Hynes NE, Badache A, Leahy DJ
RL J Biol Chem. 2008 Feb 1;283(5):2734-40. |
| Genome Property | GenProp1063: Memo/AMMECR1/rSAM family trio system (HMM) |
