HMM Summary Page: TIGR04336

FunctionAmmeMemoRadiSam system protein B
Gene SymbolamrB
Trusted Cutoff26.00
Domain Trusted Cutoff26.00
Noise Cutoff20.00
Domain Noise Cutoff20.00
Isology Typehypoth_equivalog
HMM Length270
AuthorHaft DH
Entry DateJun 5 2012 12:22PM
Last ModifiedAug 12 2012 6:56PM
CommentMembers of this protein family belong to the same domain family as the mammalian protein Memo (Mediator of ErbB2-driven cell MOtility). Members of the present family occur as part of a three gene system with an uncharacterized radical SAM enzyme and a homolog of the mammalian protein AMMECR1, a mammalian protein named for AMME - Alport syndrome, Mental Retardation, Midface hypoplasia, and Elliptocytosis. Memo in humans has protein-protein interaction activity with binding of phosphorylated Try, but members of this family may be active as enzymes, as suggested by homology to a class of nonheme iron dioxygenases.
ReferencesRN [1] RM PMID:18045866 RT Memo is homologous to nonheme iron dioxygenases and binds an ErbB2-derived phosphopeptide in its vestigial active site. RA Qiu C, Lienhard S, Hynes NE, Badache A, Leahy DJ RL J Biol Chem. 2008 Feb 1;283(5):2734-40.
Genome PropertyGenProp1063: Memo/AMMECR1/rSAM family trio system (HMM)