HMM Summary Page: TIGR04322

Functionputative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE
Trusted Cutoff200.00
Domain Trusted Cutoff200.00
Noise Cutoff160.00
Domain Noise Cutoff160.00
Isology Typeequivalog
HMM Length215
AuthorHaft DH
Entry DateMay 3 2012 4:13PM
Last ModifiedAug 12 2012 6:56PM
CommentMembers of this radical SAM domain protein family appear to be the E. coli form of the queuosine biosynthesis protein QueE. QueE is involved in making preQ0 (7-cyano-7-deazaquanine), a precursor of both the bacterial/eukaryotic modified tRNA base queuosine and the archaeal modified base archaeosine. Members occur in species that lack known forms of QueE but usually are not found in queuosine biosynthesis operons. Members of this family tend to form bi-directional best hit matches to members of known (TIGR03365) and putative (TIGR03963) QueE families from other lineages.