HMM Summary Page: TIGR04320

FunctionSEC10/PgrA surface exclusion domain
Trusted Cutoff70.00
Domain Trusted Cutoff70.00
Noise Cutoff65.00
Domain Noise Cutoff65.00
Isology Typedomain
HMM Length360
AuthorHaft DH
Entry DateApr 30 2012 5:17PM
Last ModifiedAug 12 2012 6:56PM
CommentThis model describes a conserved domain found in surface proteins of a number of Firmutes. Many members have LPXTG C-terminal anchoring motifs and a substantial number have the KxYKxGKxW putative sorting signal at the N-terminus. The tetracycline resistance plasmid pCF10 in Enterococcus faecalis promotes conjugal plasmid transfer in response to sex pheromones, but PgrA/Sec10 encoded by that plasmid, a member of this family, specifically inhibits the ability of cells to receive homologous plasmids. The phenomenon is called surface exclusion.
ReferencesRN [1] RM PMID:3936037 RT Induction of surface exclusion (entry exclusion) by Streptococcus faecalis sex pheromones: use of monoclonal antibodies to identify an inducible surface antigen involved in the exclusion process. RA Dunny GM, Zimmerman DL, Tortorello ML RL Proc Natl Acad Sci U S A. 1985 Dec;82(24):8582-6. RN [2] RM PMID:1938961 RT Molecular and genetic analysis of a region of plasmid pCF10 containing positive control genes and structural genes encoding surface proteins involved in pheromone-inducible conjugation in Enterococcus faecalis. RA Kao SM, Olmsted SB, Viksnins AS, Gallo JC, Dunny GM RL J Bacteriol. 1991 Dec;173(23):7650-64. RN [3] RM PMID:1603060 RT Sex pheromone plasmid pAD1-encoded surface exclusion protein of Enterococcus faecalis. RA Weidlich G, Wirth R, Galli D RL Mol Gen Genet. 1992 May;233(1-2):161-8.