HMM Summary Page: TIGR04313

Functionaromatic cluster surface protein
Trusted Cutoff40.00
Domain Trusted Cutoff28.00
Noise Cutoff28.50
Domain Noise Cutoff26.00
Isology Typesubfamily
HMM Length296
AuthorHaft DH
Entry DateApr 12 2012 12:35PM
Last ModifiedAug 12 2012 6:56PM
CommentMembers of this family are absolutely restricted to the Mollicutes (Mycoplasma and Ureaplasma). All have a signal peptide, usually of the lipoprotein type, suggesting surface expression. Most members have lengths of about 280 residues but some members have a nearly full-length duplication. The mostly nearly invariant residue, a Trp,is part of a strongly conserved 9-residue motif, [ND]-W-[LY]-[WF]-X-[LF]-X-N-[LI], where X usually is hydrophobic. Because the hydrophobic six-residue core of this motif almost always contains three to four aromatic residues, we name this family aromatic cluster surface protein. Multiple paralogs may occur in a given Mycoplasma, usually clustered on the genome.