HMM Summary Page: TIGR04310

Functionpantocin A family RiPP
Trusted Cutoff35.00
Domain Trusted Cutoff35.00
Noise Cutoff22.00
Domain Noise Cutoff21.00
Isology Typesubfamily
HMM Length29
AuthorHaft DH
Entry DateApr 5 2012 4:45PM
Last ModifiedAug 12 2012 6:56PM
CommentMembers of this family are ribosomally-synthesized and posttranslationally-modified peptide (RiPP) precursors about 30 amino acids in length encoded in the vicinity of PaaA and PaaB homologs. Members include PaaP from Pantoea agglomerans, whose central tripeptide EEN appears to be the source of the mature product, pantocin A. Note, however, that the corresponding residues in Photobacterium sp. SKA34 and Photobacterium asymbiotica are EEK rather than EEN. This family, therefore, resembles the PQQ precursor PqqA as a peptide precursor of an extremely small mature product.
ReferencesRN [1] RM PMID:21789243 RT Metabolic versatility and antibacterial metabolite biosynthesis are distinguishing genomic features of the fire blight antagonist Pantoea vagans C9-1. RA Smits TH, Rezzonico F, Kamber T, Blom J, Goesmann A, Ishimaru CA, Frey JE, Stockwell VO, Duffy B RL PLoS One. 2011;6(7):e22247.