HMM Summary Page: TIGR04306

Functionthiaminase II
Gene SymboltenA
Trusted Cutoff130.00
Domain Trusted Cutoff130.00
Noise Cutoff120.00
Domain Noise Cutoff120.00
Isology Typeequivalog
EC Number3.5.99.2
HMM Length208
AuthorHaft DH
Entry DateMar 28 2012 6:10PM
Last ModifiedMar 28 2012 6:10PM
CommentThe TenA protein of Bacillus subtilis and Staphylococcus aurues, and the C-terminal region of trifunctional protein Thi20p from Saccharomyces cerevisiae, perform cleavages on thiamine and related compounds to produce 4-amino-5-hydroxymethyl-2-methylpyrimidine (HMP), a substrate a salvage pathway for thiamine biosynthesis. The gene symbol tenA, for Transcription ENhancement A, reflects a misleading early characterization as a regulatory protein. This family is related to PqqC from the PQQ biosynthesis system (see TIGR02111), heme oxygenase (PF01126), and CADD (Chlamydia protein Associating with Death Domains), a putative folate metabolism enzyme (see TIGR04305).
ReferencesRN [1] RM PMID:18028398 RT Involvement of thiaminase II encoded by the THI20 gene in thiamin salvage of Saccharomyces cerevisiae. RA Onozuka M, Konno H, Kawasaki Y, Akaji K, Nosaka K RL FEMS Yeast Res. 2008 Mar;8(2):266-75. RN [2] RM PMID:21206023 RT Purification, crystallization and preliminary X-ray diffraction analysis of the thiaminase type II from Staphylococcus aureus. RA Begum A, Drebes J, Perbandt M, Wrenger C, Betzel C RL Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Jan 1;67(Pt 1):51-3. RN [3] RM PMID:15709744 RT Structural characterization of the regulatory proteins TenA and TenI from Bacillus subtilis and identification of TenA as a thiaminase II. RA Toms AV, Haas AL, Park JH, Begley TP, Ealick SE RL Biochemistry. 2005 Feb 22;44(7):2319-29.