HMM Summary Page: TIGR04305

Functionputative folate metabolism protein, CADD family
Trusted Cutoff200.00
Domain Trusted Cutoff200.00
Noise Cutoff175.00
Domain Noise Cutoff175.00
Isology Typesubfamily
HMM Length212
AuthorHaft DH
Entry DateMar 28 2012 12:51PM
Last ModifiedAug 12 2012 6:56PM
CommentThis protein family, related to but outside the family of PqqC proteins involved in PQQ biosynthesis, includes the well-studied Chlamydia protein CADD (Chlamydia protein Associating with Death Domains), which can induce apoptosis in a host cell. Other members of this family occur in Rickettsia and Wolbachia, unrelated in terms of phylogeny (both are alphaproteobacteria) but similar in living intracellularly. Local gene context in these species, although not in Trichodesmium or Nitrosomonas eutropha, suggests a role in folate metabolism, and some species with this protein lack FolE but have other folate synthesis proteins.
ReferencesRN [1] RM PMID:15087448 RT Structure of the Chlamydia protein CADD reveals a redox enzyme that modulates host cell apoptosis. RA Schwarzenbacher R, Stenner-Liewen F, Liewen H, Robinson H, Yuan H, Bossy-Wetzel E, Reed JC, Liddington RC RL J Biol Chem. 2004 Jul 9;279(28):29320-4. RN [2] RM PMID:17645794 RT Comparative genomics of bacterial and plant folate synthesis and salvage: predictions and validations. RA de Crecy-Lagard V, El Yacoubi B, de la Garza RD, Noiriel A, Hanson AD RL BMC Genomics. 2007 Jul 23;8:245.