HMM Summary Page: TIGR04298

Functionhistidine-histamine antiporter
Trusted Cutoff750.00
Domain Trusted Cutoff750.00
Noise Cutoff725.00
Domain Noise Cutoff725.00
Isology Typeequivalog
HMM Length429
AuthorHaft DH
Entry DateMar 22 2012 3:40PM
Last ModifiedMar 22 2012 4:50PM
CommentMembers of this protein family are antiporters that exchange histidine with histamine, product of histidine decarboxylation. A system consisting of this protein, and a histidine decarboxylase encoded by an adjacent gene, creates decarboxylation/antiport proton-motive cycle that provides a transient resistance to acidic conditions.
ReferencesRN [1] RM PMID:22247134 RT Evidence of two functionally distinct ornithine decarboxylation systems in lactic Acid bacteria. RA Romano A, Trip H, Lonvaud-Funel A, Lolkema JS, Lucas PM RL Appl Environ Microbiol. 2012 Mar;78(6):1953-61.
Genome PropertyGenProp0872: decarboxylation/antiport proton-motive cycle: histidine-histamine (HMM)