HMM Summary Page: TIGR04274

FunctionDNA-deoxyinosine glycosylase
Trusted Cutoff80.00
Domain Trusted Cutoff80.00
Noise Cutoff50.00
Domain Noise Cutoff50.00
Isology Typeequivalog
EC Number3.2.2.15
HMM Length150
AuthorHaft DH
Entry DateFeb 1 2012 2:12PM
Last ModifiedFeb 1 2012 3:01PM
CommentMembers of this protein family represent family 6 of the uracil-DNA glycosylase superfamily, where the five previously described families all act as uracil-DNA glycosylase (EC per se. This family, instead, acts as a hypoxanthine-DNA glycosylase, where hypoxanthine results from deamination of adenine. Activity was shown directly for members from Methanosarcina barkeri and Methanosarcina acetivorans.
ReferencesRN [1] RM PMID:21642431 RT New family of deamination repair enzymes in uracil-DNA glycosylase superfamily. RA Lee HW, Dominy BN, Cao W RL J Biol Chem. 2011 Sep 9;286(36):31282-7.