HMM Summary Page: TIGR04273

Functionsulfation-dependent quorum factor, Ax21 family
Trusted Cutoff250.00
Domain Trusted Cutoff250.00
Noise Cutoff100.00
Domain Noise Cutoff100.00
Isology Typeequivalog
HMM Length186
AuthorHaft DH
Entry DateFeb 1 2012 10:16AM
Last ModifiedFeb 1 2012 10:21AM
CommentThis family consists of proteins closely related to Ax21 (Activator of XA21-mediated immunity), a protein that is secreted by a type I secretion system (RaxABC), and that appears to be sulfated on an N-terminal region tryosine in a motif LSYN. Ax21 acts in a quorum-sensing system. Homologous peptide-mediated quorum-sensing systems appear to exist in other species, such as the emerging opportunistic pathogen Stenotrophomonas maltophilia. Intriguingly, the rice genome encodes a receptor (XA21) for this protein that triggers innate immunity.
ReferencesRN [1] RM PMID:22204763 RT Small protein-mediated quorum sensing in a Gram-negative bacterium: novel targets for control of infectious disease. RA Ronald PC RL Discov Med. 2011 Dec;12(67):461-70.