HMM Summary Page: TIGR04270

Functionmethylamine methyltransferase corrinoid protein reductive activase
Trusted Cutoff500.00
Domain Trusted Cutoff500.00
Noise Cutoff200.00
Domain Noise Cutoff200.00
Isology Typesubfamily
HMM Length534
AuthorHaft DH
Entry DateJan 24 2012 2:29PM
Last ModifiedJan 24 2012 2:37PM
CommentMembers of this family occur as paralogs in species capable of generating methane from mono-, di-, and tri-methylamine. Members include RamA (Reductive Activation of Methyltransfer, Amines) from Methanosarcina barkeri MS (DSM 800). Member proteins have two C-terminal motifs with four Cys each, likely to bind one 4Fe-4S cluster per motif.
ReferencesRN [1] RM PMID:19043046 RT RamA, a protein required for reductive activation of corrinoid-dependent methylamine methyltransferase reactions in methanogenic archaea. RA Ferguson T, Soares JA, Lienard T, Gottschalk G, Krzycki JA RL J Biol Chem. 2009 Jan 23;284(4):2285-95.