HMM Summary Page: TIGR04267

FunctionHEXXH motif domain
Trusted Cutoff25.00
Domain Trusted Cutoff25.00
Noise Cutoff24.00
Domain Noise Cutoff24.00
Isology Typedomain
HMM Length399
AuthorHaft DH
Entry DateJan 22 2012 2:03PM
Last ModifiedFeb 10 2012 10:37AM
CommentSome proteins with this domain toward the C-terminus have an N-terminal region with a radical SAM domain (PF04055) and a SPASM domain (TIGR04085), a combination frequently associated with peptide modification. All seed alignment members, and all family members that are not fused to a radical SAM domain, have a motif HEXXH that suggests metalloprotease activity. A role in peptide or protein maturation is suggested.