HMM Summary Page: TIGR04265

Functioncardiolipin synthase
Gene Symbolcls
Trusted Cutoff290.00
Domain Trusted Cutoff290.00
Noise Cutoff280.00
Domain Noise Cutoff280.00
Isology Typeequivalog
EC Number2.7.8.-
HMM Length483
AuthorHaft DH
Entry DateJan 9 2012 4:46PM
Last ModifiedJan 10 2012 3:01PM
CommentThis model is based on experimentally characterized bacterial cardiolipin synthases (cls) from E. coli, Staphylococcus aureus (two), and Bacillus pseudofirmus OF4. This model describes just one of several homologous but non-orthologous forms of cls. The cutoff score is set arbitrarily high to avoid false-positives. Note that there are two enzymatic activites called cardiolipin synthase. This model represents type 1, which does not rely on a CDP-linked donor, but instead does a reversible transfer of a phosphatidyl group from one phosphatidylglycerol molecule to another.
ReferencesRN [1] RM PMID:9370333 RT Cardiolipin synthase from Escherichia coli. RA Tropp BE RL Biochim Biophys Acta. 1997 Sep 4;1348(1-2):192-200.