HMM Summary Page: TIGR04263

FunctionSasC/Mrp/FmtB intercellular aggregation domain
Trusted Cutoff60.00
Domain Trusted Cutoff60.00
Noise Cutoff40.00
Domain Noise Cutoff40.00
Isology Typesubfamily_domain
HMM Length366
AuthorHaft DH
Entry DateJan 9 2012 10:48AM
Last ModifiedFeb 10 2012 10:37AM
CommentThis domain, about 375 amino acids long on average, occurs only in Staphylococcus and Streptococcus. It occurs as a non-repetitive N-terminal domain of LPXTG-anchored surface proteins, including SasC, Mrp, and FmtB. This region in SasC was shown to be involved in cell aggregation and biofilm formation, which may explain the methicillin resistance seen for Mrp and FmtB.
ReferencesRN [1] RM PMID:19851500 RT Molecular characterization of a novel Staphylococcus aureus surface protein (SasC) involved in cell aggregation and biofilm accumulation. RA Schroeder K, Jularic M, Horsburgh SM, Hirschhausen N, Neumann C, Bertling A, Schulte A, Foster S, Kehrel BE, Peters G, Heilmann C RL PLoS One. 2009 Oct 23;4(10):e7567.