HMM Summary Page: TIGR04253

Functionmesaconyl-CoA isomerase
Trusted Cutoff725.00
Domain Trusted Cutoff725.00
Noise Cutoff625.00
Domain Noise Cutoff625.00
Isology Typeequivalog
EC Number5.-.-.-
HMM Length403
AuthorHaft DH
Entry DateDec 23 2011 12:45PM
Last ModifiedFeb 10 2012 10:37AM
CommentMembers of this protein family belong by homology to the family of CoA transferases. However, the characterized member from Chloroflexus aurantiacus appears to perform an intramolecular transfer, making it an isomerase. The enzyme converts mesaconyl-C1-CoA to mesaconyl-C4-CoA as part of the bicyclic 3-hydroxyproprionate pathway for carbon fixation.
ReferencesRN [1] RM PMID:19955419 RT Identifying the missing steps of the autotrophic 3-hydroxypropionate CO2 fixation cycle in Chloroflexus aurantiacus. RA Zarzycki J, Brecht V, Muller M, Fuchs G RL Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21317-22.