HMM Summary Page: TIGR04240

Functionflavivirus envelope glycoprotein E, stem/anchor domain
Trusted Cutoff26.00
Domain Trusted Cutoff25.20
Noise Cutoff25.00
Domain Noise Cutoff24.80
Isology Typeequivalog_domain
HMM Length97
AuthorHaft DH
Entry DateNov 22 2011 5:07PM
Last ModifiedNov 22 2011 5:59PM
CommentThis model describes the C-terminal domain, containing a stem region followed by two transmembrane anchor domains, of the envelope protein E. This protein is cleaved from the large flavivirus polyprotein, which yields three structural and seven nonstructural proteins.
ReferencesRN [1] RM PMID:21325407 RT The unique transmembrane hairpin of flavivirus fusion protein E is essential for membrane fusion. RA Fritz R, Blazevic J, Taucher C, Pangerl K, Heinz FX, Stiasny K RL J Virol. 2011 May;85(9):4377-85. Epub 2011 Feb 16.