| Accession | TIGR04220 |
| Name | patB_acyB_mcaB |
| Function | cyanobactin biosynthesis protein, PatB/AcyB/McaB family |
| Trusted Cutoff | 55.00 |
| Domain Trusted Cutoff | 55.00 |
| Noise Cutoff | 33.00 |
| Domain Noise Cutoff | 25.00 |
| Isology Type | hypoth_equivalog |
| HMM Length | 61 |
| Author | Haft DH |
| Entry Date | Oct 27 2011 10:39AM |
| Last Modified | Oct 27 2011 10:52AM |
| Comment | Members of this protein family are small (~ 80 amino acids) and occur in biosynthesis clusters for cyanobactins, a type of ribosomal natural product, thiazole/oxazole-modified microcin (TOMM). The function of this protein family is unknown, and the recognized cyanobactin precursors (e.g. microcyclamides and patellamides) are encoded by a different protein (see TIGR03678). In this protein family, however, a core region of about 62 amino acids (modeled) is followed by a hypervariable region of 5 to 23 amino acids, with hallmarks of possible cyclodehydratase modification sites. The hallmarks include Cys residues flanked by Gly, and variable length Ser-rich tripeptide repeats. Further, members of this family were shown dispensible for patellamide biosynthesis, and two may occur in a cluster. Therefore, this family may represent a precursor of another type of ribosomal natural product. |
| References | RN [1]
RM PMID:18245249
RT Microcyclamide biosynthesis in two strains of Microcystis aeruginosa: from structure to genes and vice versa.
RA Ziemert N, Ishida K, Quillardet P, Bouchier C, Hertweck C, de Marsac NT, Dittmann E
RL Appl Environ Microbiol. 2008 Mar;74(6):1791-7.
RN [2]
RM PMID:20008171
RT Highly diverse cyanobactins in strains of the genus Anabaena.
RA Leikoski N, Fewer DP, Jokela J, Wahlsten M, Rouhiainen L, Sivonen K
RL Appl Environ Microbiol. 2010 Feb;76(3):701-9. |
| Genome Property | GenProp1083: cyanobactin-like ribosomal natural product biosynthesis (HMM) |
