HMM Summary Page: TIGR04218

Functionribosomal natural product, plantazolicin-class
Trusted Cutoff45.00
Domain Trusted Cutoff40.00
Noise Cutoff30.00
Domain Noise Cutoff25.00
Isology Typesubfamily
HMM Length43
AuthorHaft DH
Entry DateOct 26 2011 10:40AM
Last ModifiedOct 26 2011 2:17PM
CommentMembers of this protein family are precursors of TOMMs, that is, thizazole/oxazole-modified microcins. Members are about 42 residues in length, have a C-terminal region of extremely low complexity rich in Ser, and are often missed by ab initio gene callers. The plantazolicin from Bacillus amyloliquefaciens FZB42 is a peptide antibiotic effective against Bacillus anthracis.
ReferencesRN [1] RM PMID:21950656 RT Structure Determination and Interception of Biosynthetic Intermediates for the Plantazolicin Class of Highly Discriminating Antibiotics. RA Molohon KJ, Melby JO, Lee J, Evans BS, Dunbar KL, Bumpus SB, Kelleher NL, Mitchell DA RL ACS Chem Biol. 2011 Oct 6.