HMM Summary Page: TIGR04202
Accession | TIGR04202 |
Name | capSnatchArena |
Function | RNA endonuclease, cap-snatching |
Trusted Cutoff | 40.00 |
Domain Trusted Cutoff | 40.00 |
Noise Cutoff | 25.00 |
Domain Noise Cutoff | 25.00 |
Isology Type | signature |
EC Number | 3.1.-.- |
HMM Length | 61 |
Author | Haft DH |
Entry Date | Sep 19 2011 2:09PM |
Last Modified | Sep 19 2011 2:09PM |
Comment | This HMM describes a shared signature region from an RNA endonuclease region associated with cap-snatching for mRNA production by RNA viruses. This domain usually is part of a multifunctional protein, the L protein responsible for RNA-dependent RNA polymerase activity. Cap-snatching is a viral alternative to synthesizing a eukaryotic-like mRNA cap itself. |
References | RN [1] RM PMID:20862324 RT The N-terminal domain of the arenavirus L protein is an RNA endonuclease essential in mRNA transcription. RA Morin B, Coutard B, Lelke M, Ferron F, Kerber R, Jamal S, Frangeul A, Baronti C, Charrel R, de Lamballerie X, Vonrhein C, Lescar J, Bricogne G, Gunther S, Canard B RL PLoS Pathog. 2010 Sep 16;6(9):e1001038. |