HMM Summary Page: TIGR04202

FunctionRNA endonuclease, cap-snatching
Trusted Cutoff40.00
Domain Trusted Cutoff40.00
Noise Cutoff25.00
Domain Noise Cutoff25.00
Isology Typesignature
EC Number3.1.-.-
HMM Length61
AuthorHaft DH
Entry DateSep 19 2011 2:09PM
Last ModifiedSep 19 2011 2:09PM
CommentThis HMM describes a shared signature region from an RNA endonuclease region associated with cap-snatching for mRNA production by RNA viruses. This domain usually is part of a multifunctional protein, the L protein responsible for RNA-dependent RNA polymerase activity. Cap-snatching is a viral alternative to synthesizing a eukaryotic-like mRNA cap itself.
ReferencesRN [1] RM PMID:20862324 RT The N-terminal domain of the arenavirus L protein is an RNA endonuclease essential in mRNA transcription. RA Morin B, Coutard B, Lelke M, Ferron F, Kerber R, Jamal S, Frangeul A, Baronti C, Charrel R, de Lamballerie X, Vonrhein C, Lescar J, Bricogne G, Gunther S, Canard B RL PLoS Pathog. 2010 Sep 16;6(9):e1001038.