HMM Summary Page: TIGR04198

FunctionmRNA capping enzyme
Trusted Cutoff185.00
Domain Trusted Cutoff185.00
Noise Cutoff50.00
Domain Noise Cutoff50.00
Isology Typeequivalog_domain
HMM Length938
AuthorHaft DH
Entry DateSep 16 2011 2:24PM
Last ModifiedDec 19 2011 9:54AM
CommentThis model represents a common C-terminal region shared by paramyxovirus-like RNA-dependent RNA polymerases (see Pfam model PF00946). Polymerase proteins described by these two models are often called L protein (large polymerase protein). Capping of mRNA requires RNA triphosphatase and guanylyl transferase activities, demonstrated for the rinderpest virus L protein and at least partially localized to the region of this model.
ReferencesRN [1] RM PMID:19297608 RT RNA triphosphatase and guanylyl transferase activities are associated with the RNA polymerase protein L of rinderpest virus. RA Gopinath M, Shaila MS RL J Gen Virol. 2009 Jul;90(Pt 7):1748-56.