HMM Summary Page: TIGR04198
| Accession | TIGR04198 |
| Name | paramyx_RNAcap |
| Function | mRNA capping enzyme |
| Trusted Cutoff | 185.00 |
| Domain Trusted Cutoff | 185.00 |
| Noise Cutoff | 50.00 |
| Domain Noise Cutoff | 50.00 |
| Isology Type | equivalog_domain |
| HMM Length | 938 |
| Author | Haft DH |
| Entry Date | Sep 16 2011 2:24PM |
| Last Modified | Dec 19 2011 9:54AM |
| Comment | This model represents a common C-terminal region shared by paramyxovirus-like RNA-dependent RNA polymerases (see Pfam model PF00946). Polymerase proteins described by these two models are often called L protein (large polymerase protein). Capping of mRNA requires RNA triphosphatase and guanylyl transferase activities, demonstrated for the rinderpest virus L protein and at least partially localized to the region of this model. |
| References | RN [1] RM PMID:19297608 RT RNA triphosphatase and guanylyl transferase activities are associated with the RNA polymerase protein L of rinderpest virus. RA Gopinath M, Shaila MS RL J Gen Virol. 2009 Jul;90(Pt 7):1748-56. |