HMM Summary Page: TIGR04193

FunctionSPASM domain peptide maturase, grasp-with-spasm system
Gene SymbolgwsS
Trusted Cutoff175.00
Domain Trusted Cutoff175.00
Noise Cutoff125.00
Domain Noise Cutoff125.00
Isology Typeequivalog
HMM Length342
AuthorHaft DH
Entry DateAug 17 2011 5:32PM
Last ModifiedFeb 10 2012 10:37AM
CommentA 4Fe-4S-binding C-terminal domain is shared by radical SAM maturases for Subtilosin A (S), PQQ (P), Anaerobic sulfatases (AS), and mycofactocin (M), hence SPASM. Radical SAM proteins with SPASM tend to be peptide maturases. All members of this family, like some members of the quasi-rSAM family TIGR04105, lack the 4Fe-4S cluster of the radical SAM domain (PF04055) in the N-terminal region. Members of this family occur with an ATP-GRASP family protein, known as a possible maturase from microviridin biosynthetic clusters. Systems occur in Microscilla marina ATCC 23134, Kordia algicida OT-1, Sphingobacterium spiritivorum ATCC 33300, etc.
Genome PropertyGenProp1002: grasp-with-spasm peptide maturase system (HMM)