HMM Summary Page: TIGR04191
| Accession | TIGR04191 |
| Name | YphP_YqiW |
| Function | putative bacilliredoxin, YphP/YqiW family |
| Trusted Cutoff | 100.00 |
| Domain Trusted Cutoff | 100.00 |
| Noise Cutoff | 25.00 |
| Domain Noise Cutoff | 25.00 |
| Isology Type | subfamily |
| EC Number | 1.-.-.- |
| HMM Length | 136 |
| Author | Haft DH |
| Entry Date | Aug 16 2011 5:34PM |
| Last Modified | Aug 16 2011 5:34PM |
| Comment | This protein family is one of several observed in species that express bacillithiol, an analog of glutathione and mycothiol. Rather than being involved in bacillithiol biosynthesis, members are likely to act in bacillithiol-dependent processes. A suggested term is bacilliredoxin (a glutaredoxin-like thiol-dependent oxidoreductase), and a suggested role of YphP is de-bacillithiolation - removing bacillithiol that became linked to protein thiols under oxidative stress. An older description of YphP as a disulphide isomerase therefore may be wrong. |
| References | RN [1] RM PMID:21749987 RT S-bacillithiolation protects against hypochlorite stress in Bacillus subtilis as revealed by transcriptomics and redox proteomics. RA Chi BK, Gronau K, Mader U, Hessling B, Becher D, Antelmann H RL Mol Cell Proteomics. 2011 Nov;10(11):M111.009506. doi: 10.1074/mcp.M111.009506. RN [2] RM PMID:20712413 RT Bacillithiol, a new player in bacterial redox homeostasis. RA Helmann JD RL Antioxid Redox Signal. 2011 Jul 1;15(1):123-33. doi: 10.1089/ars.2010.3562. RN [3] RM PMID:22938038 RT S-bacillithiolation protects conserved and essential proteins against hypochlorite stress in firmicutes bacteria. RA Chi BK, Roberts AA, Huyen TT, Basell K, Becher D, Albrecht D, Hamilton CJ, Antelmann H RL Antioxid Redox Signal. 2013 Apr 10;18(11):1273-95. doi: 10.1089/ars.2012.4686. |