HMM Summary Page: TIGR04191

Functionputative bacilliredoxin, YphP/YqiW family
Trusted Cutoff100.00
Domain Trusted Cutoff100.00
Noise Cutoff25.00
Domain Noise Cutoff25.00
Isology Typesubfamily
EC Number1.-.-.-
HMM Length136
AuthorHaft DH
Entry DateAug 16 2011 5:34PM
Last ModifiedAug 16 2011 5:34PM
CommentThis protein family is one of several observed in species that express bacillithiol, an analog of glutathione and mycothiol. Rather than being involved in bacillithiol biosynthesis, members are likely to act in bacillithiol-dependent processes. A suggested term is bacilliredoxin (a glutaredoxin-like thiol-dependent oxidoreductase), and a suggested role of YphP is de-bacillithiolation - removing bacillithiol that became linked to protein thiols under oxidative stress. An older description of YphP as a disulphide isomerase therefore may be wrong.
ReferencesRN [1] RM PMID:21749987 RT S-bacillithiolation protects against hypochlorite stress in Bacillus subtilis as revealed by transcriptomics and redox proteomics. RA Chi BK, Gronau K, Mader U, Hessling B, Becher D, Antelmann H RL Mol Cell Proteomics. 2011 Nov;10(11):M111.009506. doi: 10.1074/mcp.M111.009506. RN [2] RM PMID:20712413 RT Bacillithiol, a new player in bacterial redox homeostasis. RA Helmann JD RL Antioxid Redox Signal. 2011 Jul 1;15(1):123-33. doi: 10.1089/ars.2010.3562. RN [3] RM PMID:22938038 RT S-bacillithiolation protects conserved and essential proteins against hypochlorite stress in firmicutes bacteria. RA Chi BK, Roberts AA, Huyen TT, Basell K, Becher D, Albrecht D, Hamilton CJ, Antelmann H RL Antioxid Redox Signal. 2013 Apr 10;18(11):1273-95. doi: 10.1089/ars.2012.4686.