HMM Summary Page: TIGR04180

FunctionNAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family
Trusted Cutoff475.00
Domain Trusted Cutoff475.00
Noise Cutoff365.00
Domain Noise Cutoff365.00
Isology Typehypoth_equivalog
HMM Length297
AuthorSelengut J
Entry DateJul 8 2011 3:29PM
Last ModifiedAug 16 2011 12:37PM
CommentThis clade within the NAD dependent epimerase/dehydratase superfamily (PF01370) is characterized by inclusion of its members within a cassette of seven distinctive enzymes. These include four genes homologous to the elements of the neuraminic (sialic) acid biosynthesis cluster (NeuABCD), an aminotransferase and a nucleotidyltransferase in addition to the epimerase/dehydratase. Together it is very likely that these enzymes direct the biosynthesis of a nine-carbon sugar analagous to CMP-neuraminic acid. These seven genes form the core of the cassette, although they are often accompanied by additional genes that may further modify the product sugar. Although this cassette is widely distributed in bacteria, the family nomenclature arises from the instance in Leptospira interrogans serovar Lai, str. 56601, where it appears as the 30th gene in the 91-gene lipopolysaccharide biosynthesis cluster.
Genome PropertyGenProp0997: proposed nine-carbon sugar biosynthesis cassette (HMM)