HMM Summary Page: TIGR04170

Functionribonucleoside-diphosphate reductase, class 1b, alpha subunit
Gene SymbolnrdE
Trusted Cutoff750.00
Domain Trusted Cutoff750.00
Noise Cutoff500.00
Domain Noise Cutoff500.00
Isology Typeexception
EC Number1.17.4.1
HMM Length698
AuthorHaft DH
Entry DateMay 27 2011 10:54AM
Last ModifiedMay 27 2011 11:00AM
CommentMembers of this family are NrdE, the alpha subunit of class 1b ribonucleotide reductase. This form uses a dimanganese moiety associated with a tyrosine radical to reduce the cellular requirement for iron.
ReferencesRN [1] RM PMID:21561096 RT Bacillus subtilis Class Ib Ribonucleotide Reductase is a Dimanganese(III)-Tyrosyl Radical Enzyme. RA Zhang Y, Stubbe J RL Biochemistry. 2011 May 11.