HMM Summary Page: TIGR04158

Function3-methyl-2-indolic acid synthase
Gene SymbolnocL
Trusted Cutoff400.00
Domain Trusted Cutoff400.00
Noise Cutoff260.00
Domain Noise Cutoff260.00
Isology Typeequivalog
EC Number4.1.-.-
HMM Length368
AuthorHaft DH
Entry DateApr 27 2011 2:25PM
Last ModifiedApr 27 2011 2:29PM
CommentMembers are a radical SAM enzyme that converts L-Trp to 3-methyl-2-indolic acid synthase through a complex rearrangement. This enzyme is closest to ThiH, which also does a complex rearrangement, among other characterized radical SAM enzymes.
ReferencesRN [1] RM PMID:21454624 RT Characterization of NocL involved in thiopeptide nocathiacin I biosynthesis: A [4Fe-4S] cluster and the catalysis of a radical S-adenosylmethionine enzyme. RA Zhang Q, Chen D, Lin J, Liao R, Tong W, Xu Z, Liu W RL J Biol Chem. 2011 Mar 29. RN [2] RM PMID:21240261 RT Radical-mediated enzymatic carbon chain fragmentation-recombination. RA Zhang Q, Li Y, Chen D, Yu Y, Duan L, Shen B, Liu W RL Nat Chem Biol. 2011 Mar;7(3):154-60. doi: 10.1038/nchembio.512.