| Accession | TIGR04150 |
| Name | pseudo_rSAM_GG |
| Function | pseudo-rSAM protein, GG-Bacteroidales system |
| Trusted Cutoff | 250.00 |
| Domain Trusted Cutoff | 250.00 |
| Noise Cutoff | 75.00 |
| Domain Noise Cutoff | 75.00 |
| Isology Type | subfamily |
| HMM Length | 407 |
| Author | Haft DH |
| Entry Date | Apr 2 2011 3:39PM |
| Last Modified | Jun 28 2012 9:52AM |
| Comment | Many peptide-modifying radical SAM enzymes have two 4Fe4S-binding regions, an N-terminal one recognized by Pfam radical SAM domain-defining model PF04055 and a C-terminal one recognized by TIGR04085. Members of this protein family occur in cassettes with such a radical SAM family (TIGR04148) and with a peptide modification target (TIGR04149). Surprisingly, members of this family show full-length homology to each other, with several scoring at least borderline hits to both PF04055 and TIGR04085, and yet differ in the presence/absence of a signature CX(3)CX(2)CX(9)C motif. Instead, members are best-conserved in the TIGR04085-like C-terminal region. Therefore, this protein family is designated a pseudo-radical-SAM protein, which likely works in partnership with a TIGR04148 family protein. |
| References | RN [1]
RM PMID:21478363
RT Biological systems discovery in silico: radical S-adenosylmethionine protein families and their target peptides for posttranslational modification.
RA Haft DH, Basu MK
RL J Bacteriol. 2011 Jun;193(11):2745-55. |
| Genome Property | GenProp0984: radical SAM maturase system, GG-Bacteroidales group (HMM) |
