HMM Summary Page: TIGR04149

Functionnatural product precursor, GG-Bacteroidales family
Trusted Cutoff25.00
Domain Trusted Cutoff25.00
Noise Cutoff22.00
Domain Noise Cutoff22.00
Isology Typedomain
HMM Length43
AuthorHaft DH
Entry DateApr 2 2011 1:46PM
Last ModifiedJun 9 2011 10:12AM
CommentSequences in this protein domain family include a leader peptide region, up to and including a Gly-Gly cleavage motif, and about 15 additional residues, usually Cys-rich, from a family of predicted ribosomal natural product precursors. Many of these are associated with peptide-modifying radical SAM enzymes. The core region, up through the diglycine motif, resembles and contains some overlapping hits with the bacteriocin precuror leader peptide region modeled by TIGR01847, but is longer with an extreme N-terminal region with consensus sequence MKKLKKLKL.
ReferencesRN [1] RM PMID:21478363 RT Biological systems discovery in silico: radical S-adenosylmethionine protein families and their target peptides for posttranslational modification. RA Haft DH, Basu MK RL J Bacteriol. 2011 Jun;193(11):2745-55.
Genome PropertyGenProp0984: radical SAM maturase system, GG-Bacteroidales group (HMM)