HMM Summary Page: TIGR04145

FunctionFirmicu-CTERM domain
Trusted Cutoff35.00
Domain Trusted Cutoff35.00
Noise Cutoff25.00
Domain Noise Cutoff25.00
Isology Typehypoth_equivalog_domain
HMM Length45
AuthorHaft DH
Entry DateMar 23 2011 5:44PM
Last ModifiedFeb 10 2012 12:42PM
CommentThis C-terminal domain is found only in the Firmicutes, where its presence is sporadically distributed. Proteins with this domain are most conserved in the C-terminal region, where the pattern of ending with a transmembrane domain resembles both the LPXTG (sortase target) and PEP-CTERM (exosortase target) domain structures. However, members occur exclusively in the presence of an exosortase-like protein XrtG (TIGR03110), a putative glycosyltransferase (TIGR03111), and a 6-pyruvoyl tetrahydropterin synthase-related protein (TIGR03112).
ReferencesRN [1] RM PMID:22037399 RT Archaeosortases and exosortases are widely distributed systems linking membrane transit with posttranslational modification. RA Haft DH, Payne SH, Selengut JD RL J Bacteriol. 2012 Jan;194(1):36-48. Epub 2011 Oct 28.
Genome PropertyGenProp0669: protein sorting system, putative, exosortase G class (HMM)