HMM Summary Page: TIGR04126

FunctionPGF-CTERM archaeal protein-sorting signal
Trusted Cutoff24.50
Domain Trusted Cutoff24.50
Noise Cutoff22.50
Domain Noise Cutoff22.50
Isology Typedomain
HMM Length28
AuthorHaft DH
Entry DateFeb 11 2011 12:11PM
Last ModifiedFeb 10 2012 10:56AM
CommentThis HMM describes a strictly archaeal putative protein-sorting motif, PGF-CTERM. It is the (predicted) recognition sequence for an exosortase homolog, archaeosortase (TIGR04125). In some archaea, up to fifty proteins have this domain as their C-terminal region, usually preceded by a Thr-rich region likely to be heavily glycosylated. The removal of this sorting signal may be associated with a C-terminal prenyl group modification in the halobacterial major cell surface glycoprotein, an S-layer protein.
ReferencesRN [1] RM PMID:22037399 RT Archaeosortases and exosortases are widely distributed systems linking membrane transit with posttranslational modification. RA Haft DH, Payne SH, Selengut JD RL J Bacteriol. 2012 Jan;194(1):36-48.
Genome PropertyGenProp0978: protein sorting system, PGF-CTERM/archaeosortase A (HMM)