| Accession | TIGR04126 |
| Name | PGF_CTERM |
| Function | PGF-CTERM archaeal protein-sorting signal |
| Trusted Cutoff | 24.50 |
| Domain Trusted Cutoff | 24.50 |
| Noise Cutoff | 22.50 |
| Domain Noise Cutoff | 22.50 |
| Isology Type | domain |
| HMM Length | 28 |
| Author | Haft DH |
| Entry Date | Feb 11 2011 12:11PM |
| Last Modified | Feb 10 2012 10:56AM |
| Comment | This HMM describes a strictly archaeal putative protein-sorting motif, PGF-CTERM. It is the (predicted) recognition sequence for an exosortase homolog, archaeosortase (TIGR04125). In some archaea, up to fifty proteins have this domain as their C-terminal region, usually preceded by a Thr-rich region likely to be heavily glycosylated. The removal of this sorting signal may be associated with a C-terminal prenyl group modification in the halobacterial major cell surface glycoprotein, an S-layer protein. |
| References | RN [1]
RM PMID:22037399
RT Archaeosortases and exosortases are widely distributed systems linking membrane transit with posttranslational modification.
RA Haft DH, Payne SH, Selengut JD
RL J Bacteriol. 2012 Jan;194(1):36-48. |
| Genome Property | GenProp0978: protein sorting system, PGF-CTERM/archaeosortase A (HMM) |
