| Accession | TIGR04115 |
| Name | rSAM_Cxxx_rpt |
| Function | radical SAM peptide maturase, CXXX-repeat target family |
| Trusted Cutoff | 350.00 |
| Domain Trusted Cutoff | 350.00 |
| Noise Cutoff | 200.00 |
| Domain Noise Cutoff | 200.00 |
| Isology Type | equivalog_domain |
| HMM Length | 359 |
| Author | Haft DH |
| Entry Date | Feb 7 2011 10:29AM |
| Last Modified | Aug 2 2011 2:25PM |
| Comment | Members of this radical SAM domain protein are predicted peptide maturases, similar to PqqE, AlbA, the mycofactocin radical SAM maturase, and many others that share the peptide modification radical SAM protein C-terminal additional 4Fe4S-binding domain (TIGR04085). Members co-occur with a protein of unknown function that may be a chaperone or immunity protein and with a peptide that may have twelve or more cysteines occurring regularly spaced every fourth residue. These Cys residues tend to be flanked by residues with small side chains that provide minimal steric hindrance to crosslink formation by the radical SAM enzyme as in the subtilosin A system. |
| References | RN [1]
RM PMID:21478363
RT Biological systems discovery in silico: radical S-adenosylmethionine protein families and their target peptides for posttranslational modification.
RA Haft DH, Basu MK
RL J Bacteriol. 2011 Jun;193(11):2745-55. |
| Genome Property | GenProp0967: radical SAM maturase system, CXXX repeats type (HMM) |
