HMM Summary Page: TIGR04115

Functionradical SAM peptide maturase, CXXX-repeat target family
Trusted Cutoff350.00
Domain Trusted Cutoff350.00
Noise Cutoff200.00
Domain Noise Cutoff200.00
Isology Typeequivalog_domain
HMM Length359
AuthorHaft DH
Entry DateFeb 7 2011 10:29AM
Last ModifiedAug 2 2011 2:25PM
CommentMembers of this radical SAM domain protein are predicted peptide maturases, similar to PqqE, AlbA, the mycofactocin radical SAM maturase, and many others that share the peptide modification radical SAM protein C-terminal additional 4Fe4S-binding domain (TIGR04085). Members co-occur with a protein of unknown function that may be a chaperone or immunity protein and with a peptide that may have twelve or more cysteines occurring regularly spaced every fourth residue. These Cys residues tend to be flanked by residues with small side chains that provide minimal steric hindrance to crosslink formation by the radical SAM enzyme as in the subtilosin A system.
ReferencesRN [1] RM PMID:21478363 RT Biological systems discovery in silico: radical S-adenosylmethionine protein families and their target peptides for posttranslational modification. RA Haft DH, Basu MK RL J Bacteriol. 2011 Jun;193(11):2745-55.
Genome PropertyGenProp0967: radical SAM maturase system, CXXX repeats type (HMM)