HMM Summary Page: TIGR04114

Functionmodification target Cys-rich repeat
Trusted Cutoff20.00
Domain Trusted Cutoff13.50
Noise Cutoff16.00
Domain Noise Cutoff13.30
Isology Typerepeat
HMM Length18
AuthorHaft DH
Entry DateFeb 5 2011 3:22PM
Last ModifiedAug 2 2011 2:33PM
CommentThis HMM describes a cysteine-rich repeat found in a number of bacterial putative radical-SAM modified natural product precursors. A substantial fraction of members of this family have been missed during gene-finding. A true hit to the model must exceed both TC on the whole and trusted cutoff 2 for at least one domain, to avoid false-positives from African swine fever virus proteins.
ReferencesRN [1] RM PMID:21478363 RT Biological systems discovery in silico: radical S-adenosylmethionine protein families and their target peptides for posttranslational modification. RA Haft DH, Basu MK RL J Bacteriol. 2011 Jun;193(11):2745-55.
Genome PropertyGenProp0967: radical SAM maturase system, CXXX repeats type (HMM)