HMM Summary Page: TIGR04107

Functionputative heme utilization radical SAM enzyme HutW
Gene SymbolhutW
Trusted Cutoff400.00
Domain Trusted Cutoff400.00
Noise Cutoff275.00
Domain Noise Cutoff275.00
Isology Typeequivalog
HMM Length419
AuthorHaft DH
Entry DateJan 26 2011 11:00AM
Last ModifiedFeb 14 2011 3:27PM
CommentHutW is a radical SAM enzyme closely related to HemN, the heme biosynthetic oxygen-independent coproporphyrinogen oxidase. It belongs to operons associated with heme uptake and utilization in Vibrio cholerae and related species, but neither it not HutX has been shown to be needed, as is HutZ, for heme utilization. HutW failed to complement a Salmonella enterica hemN mutant (PMID:15205415), suggesting a related but distinct activity. Some members of this family are fused to hutX.
ReferencesRN [1] RM PMID:15205415 RT HutZ is required for efficient heme utilization in Vibrio cholerae. RA Wyckoff EE, Schmitt M, Wilks A, Payne SM RL J Bacteriol. 2004 Jul;186(13):4142-51.
Genome PropertyGenProp0961: heme metabolism pair HutWX (HMM)