HMM Summary Page: TIGR04088

FunctionSipW-cognate class signal peptide
Trusted Cutoff19.00
Domain Trusted Cutoff19.00
Noise Cutoff16.00
Domain Noise Cutoff16.00
Isology Typedomain
HMM Length34
AuthorHaft DH
Entry DateNov 12 2010 2:09PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes a protein N-terminal domain found regularly in proteins encoded near a variant form of signal peptidase I such as the SipW protein of Bacillus subtilis. Many though not all members are homologs of camelysin (a casein-cleaving metalloprotease) and TasA (CotN), a metalloprotease that is secreted, along with extracellular polysaccharide (EPS), to be the major protein constituent of the Bacillus subtilis biofilm matrix. Sequencing from several known TasA/CotN proteins shows the cleavage location to be near the center of the alignment and typical of type I signal peptidases, with small residues at -3 and -1. This domain, therefore, appears to be a special subclass of signal peptide.
Genome PropertyGenProp0957: protein sorting system, SipW class (HMM)