| Accession | TIGR04085 |
| Name | rSAM_more_4Fe4S |
| Function | radical SAM additional 4Fe4S-binding SPASM domain |
| Trusted Cutoff | 27.00 |
| Domain Trusted Cutoff | 27.00 |
| Noise Cutoff | 16.00 |
| Domain Noise Cutoff | 16.00 |
| Isology Type | domain |
| HMM Length | 93 |
| Author | Haft DH |
| Entry Date | Nov 5 2010 1:36PM |
| Last Modified | Aug 25 2011 2:00PM |
| Comment | This domain contains regions binding additional 4Fe4S clusters found in various radical SAM proteins C-terminal to the domain described by model PF04055. Radical SAM enzymes with this domain tend to be involved in protein modification, including anaerobic sulfatase maturation proteins, a quinohemoprotein amine dehydrogenase biogenesis protein, the Pep1357-cyclizing radical SAM enzyme, and various bacteriocin biosynthesis proteins. The motif CxxCxxxxxCxxxC is nearly invariant for members of this family, although PqqE has a variant form. We name this domain SPASM for Subtilosin, PQQ, Anaerobic Sulfatase, and Mycofactocin. |
| References | RN [1]
RM PMID:21478363
RT Biological systems discovery in silico: radical S-adenosylmethionine protein families and their target peptides for posttranslational modification.
RA Haft DH, Basu MK
RL J Bacteriol. 2011 Jun;193(11):2745-55. Epub 2011 Apr 8.
RN [1]
RM PMID:21223593
RT Bioinformatic evidence for a widely distributed, ribosomally produced electron carrier precursor, its maturation proteins, and its nicotinoprotein redox partners.
RA Haft DH
RL BMC Genomics. 2011 Jan 11;12:21.
RN [3]
RM PMID:20218986
RT Anaerobic sulfatase-maturating enzyme--a mechanistic link with glycyl radical-activating enzymes?
RA Benjdia A, Subramanian S, Leprince J, Vaudry H, Johnson MK, Berteau O
RL FEBS J. 2010 Apr;277(8):1906-20. Epub 2010 Mar 9. |
