HMM Summary Page: TIGR04084

Functionputative peptide-modifying radical SAM enzyme, AF0577 family
Trusted Cutoff225.00
Domain Trusted Cutoff225.00
Noise Cutoff175.00
Domain Noise Cutoff175.00
Isology Typesubfamily
HMM Length347
AuthorHaft DH
Entry DateNov 2 2010 5:38PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis radical SAM family contains a C-terminal region motif CXXCX5CX3C that is found in PqqE and other radical SAM enzymes that act on peptide substrates. Members of this family are found primarily in the Archaea, but also several eukaryotes (Trichomonas vaginalis G3, Entamoeba dispar SAW760, Giardia intestinalis ATCC 50581, etc.). The function is unknown.
ReferencesRN [1] RM PMID:20218986 RT Anaerobic sulfatase-maturating enzyme--a mechanistic link with glycyl radical-activating enzymes? RA Benjdia A, Subramanian S, Leprince J, Vaudry H, Johnson MK, Berteau O RL FEBS J. 2010 Apr;277(8):1906-20.