HMM Summary Page: TIGR04079

FunctionKxxxW-cyclized secreted peptide
Trusted Cutoff35.00
Domain Trusted Cutoff20.00
Noise Cutoff25.00
Domain Noise Cutoff18.00
Isology Typesubfamily
HMM Length23
AuthorHaft DH
Entry DateOct 29 2010 9:39AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are short precursor peptides in which the mature form undergoes a cyclization between a Lys and a Trp four residues away. The modification enzyme appears to be an adjacent encoded radical SAM protein. Genomes encoding this system include Streptococcus thermophilus LMD-9 and Lactococcus lactis subsp. cremoris MG1363, among others.
ReferencesRN [1] RM PMID:17921293 RT Control of the transcription of a short gene encoding a cyclic peptide in Streptococcus thermophilus: a new quorum-sensing system? RA Ibrahim M, Guillot A, Wessner F, Algaron F, Besset C, Courtin P, Gardan R, Monnet V RL J Bacteriol. 2007 Dec;189(24):8844-54. Epub 2007 Oct 5.
Genome PropertyGenProp0954: radical SAM-cylized peptide, Pep1357C family (HMM)