HMM Summary Page: TIGR04078

Functionpeptide modification radical SAM enzyme, YydG family
Trusted Cutoff300.00
Domain Trusted Cutoff300.00
Noise Cutoff220.00
Domain Noise Cutoff220.00
Isology Typeequivalog
HMM Length309
AuthorHaft DH
Entry DateOct 28 2010 1:13PM
Last ModifiedJul 5 2011 12:52PM
CommentMembers of this radical SAM protein family for peptide modification occur only in the context of members of family TIGR04077, which average about 50 amino acids in length. In Bacillus subtilis, this protein (YydG) appears to act on its cognate target peptide (YydF) prior to its export, and result in the creation of a signaling molecule that induces the LiaRS two-component system.
ReferencesRN [1] RM PMID:17921301 RT The yydFGHIJ operon of Bacillus subtilis encodes a peptide that induces the LiaRS two-component system. RA Butcher BG, Lin YP, Helmann JD RL J Bacteriol. 2007 Dec;189(23):8616-25. Epub 2007 Oct 5. RN [2] RM PMID:21478363 RT Biological systems discovery in silico: radical S-adenosylmethionine protein families and their target peptides for posttranslational modification. RA Haft DH, Basu MK RL J Bacteriol. 2011 Jun;193(11):2745-55.
Genome PropertyGenProp0955: modified peptide/radical SAM maturase system, YydFG family (HMM)