HMM Summary Page: TIGR04077

Functionexported signaling peptide, YydF/SAG_2028 family
Trusted Cutoff35.00
Domain Trusted Cutoff35.00
Noise Cutoff25.00
Domain Noise Cutoff25.00
Isology Typesubfamily
HMM Length49
AuthorHaft DH
Entry DateOct 28 2010 12:27PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family describes a rare family of small proteins, about 50 residues in length, that includes YydF from Bacillus subtilis and SAG_2028 from Streptococcus agalactiae 2603V/R. Mutational analysis and genomic context show that members of this family likely are modified by a (variably present) radical SAM enzyme, are exported by an ABC transporter, and serve as signaling peptide. The member from Bacillus subtilis induces the LiaRS two-component system.
ReferencesRN [1] RM PMID:17921301 RT The yydFGHIJ operon of Bacillus subtilis encodes a peptide that induces the LiaRS two-component system. RA Butcher BG, Lin YP, Helmann JD RL J Bacteriol. 2007 Dec;189(23):8616-25. Epub 2007 Oct 5.
Genome PropertyGenProp0955: modified peptide/radical SAM maturase system, YydFG family (HMM)