HMM Summary Page: TIGR04073

Functionputative exosortase-associated protein, TIGR04073 family
Trusted Cutoff50.00
Domain Trusted Cutoff50.00
Noise Cutoff40.00
Domain Noise Cutoff40.00
Isology Typesubfamily
HMM Length75
AuthorHaft DH
Entry DateOct 13 2010 4:00PM
Last ModifiedJun 3 2011 5:05PM
CommentMembers of this protein family are found in beta, gamma, and delta proteobacteria, and in the verrucomicrobia. Twenty-two of twenty-four species encountered contain the PEP-CTERM/exosortase system for modulating extracellular polysaccharide biosynthesis production, suggesting a role in protein sorting. The N-terminal signal sequence is divergent and not included in the model. PSI-BLAST and HMM searches suggest a distant sequence relationship between a region of this protein of about 100 amino acids and a corresponding region of the very large eukaryotic protein vps13, associated with vacuolar protein sorting in yeast.