HMM Summary Page: TIGR04071

Functionmethanobactin precursor, Mb-OB3b family
Gene SymbolmbnA
Trusted Cutoff27.50
Domain Trusted Cutoff27.50
Noise Cutoff22.50
Domain Noise Cutoff22.50
Isology Typesubfamily
HMM Length30
AuthorHaft DH
Entry DateOct 10 2010 4:35PM
Last ModifiedAug 19 2014 11:39AM
CommentMethanobactins are siderophore-like copper-chelating natural products with considerable variety from species to species. The 11-residue methanobactin of Methylosinus trichosporium OB3b is derived from a 30-residue precursor. A very similar 31-residue precursor is found in the rice endophyte Azospirillum sp. B510, which has not yet been shown to produce a methanobactin. This HMM models the shared region of the first 25 amino acids, including a Cys-Gly-Ser motif.
ReferencesRN [1] RM PMID:20961038 RT A comparison of methanobactins from Methylosinus trichosporium OB3b and Methylocystis strain Sb2 predicts methanobactins are synthesized from diverse peptide precursors modified to create a common core for binding and reducing copper ions. RA Krentz BD, Mulheron HJ, Semrau JD, Dispirito AA, Bandow NL, Haft DH, Vuilleumier S, Murrell JC, McEllistrem MT, Hartsel SC, Gallagher WH RL Biochemistry. 2010 Nov 30;49(47):10117-30.
Genome PropertyGenProp0962: methanobactin biosynthesis, Mb-OB3b family (HMM)